This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison.
What are post-translational modifcations?
Post-translational modifications are chemical changes to a protein after it is translated. These changes include the addition of phosphate grouns (phosphorylation), the addition of sugar groups (glycosylation), and others. Each of these modifications can affect the function, stability, localization, and binding of the protein. [1,2]
LIPC Post-Translational Modifications
LIPC is glycosylated at three positions in its N-terminus. These are important for its secretion and function and mutations at this position significantly alter LIPC activity. LIPC is also predicted to be phosphorylated at multiple positions.
Conclusion
Post-translational modifications play a significant role in protein function. It is important to study them as they may differ by cell type and situation which enables proteins to alter their function based on the situation.
References
[1] Gruhler, A., & Jensen, O. N. (n.d.). Proteomic Analysis of Post-Translational Modifications by Mass Spectrometry. Plant Proteomics, 33-53. doi:10.1002/9780470988879.ch2
[2] Khoury, G. A., Baliban, R. C., & Floudas, C. A. (2011). Proteome-wide post-translational modification statistics: Frequency analysis and curation of the swiss-prot database. Scientific Reports, 1(1). doi:10.1038/srep00090
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[2] Khoury, G. A., Baliban, R. C., & Floudas, C. A. (2011). Proteome-wide post-translational modification statistics: Frequency analysis and curation of the swiss-prot database. Scientific Reports, 1(1). doi:10.1038/srep00090
Non-Linked Figures
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